SCOPe 2.03: Domain d3rilb1: 3ril B:1-77,B:432-497

Lineage for d3rilb1 (3ril B:1-77,B:432-497)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.71: Glycosyl hydrolase domain [51010] (1 superfamily)
   folded sheet; greek-key

4. Superfamily b.71.1: Glycosyl hydrolase domain [51011] (6 families)
   this domain is C-terminal to the catalytic beta/alpha barrel domain

5. Family b.71.1.2: Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [89388] (4 proteins)
   interrupted by the catalytic domain; the C-terminal core is similar to the alpha-amylase domain

6. Protein Glucosylceramidase [89389] (1 species)
   glycosyl hydrolase family 30; the N-terminal extension wraps around the C-terminal core

7. Species Human (Homo sapiens) [TaxId:9606] [89390] (17 PDB entries)

8. Domain d3rilb1: 3ril B:1-77,B:432-497 [215848]
   Other proteins in same PDB: d3rila2, d3rilb2, d3rilc2, d3rild2
   automated match to d1ogsa1
   complexed with 3rk, nag, so4

Details for d3rilb1

PDB Entry: 3ril, 2.4 Å

PDB Description: the acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease

PDB Compounds: (B:) glucosylceramidase

SCOPe Domain Sequences for d3rilb1:

Sequence; same for both SEQRES and ATOM records:

>d3rilb1 b.71.1.2 (B:1-77,B:432-497) Glucosylceramidase {Human (Homo sapiens) [TaxId: 9606]}
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkXqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltik
dpavgfletispgysihtylwhrq

Timeline for d3rilb1:

• d3rilb1 is new in SCOPe 2.03-stable
  
• d3rilb1 appears in SCOPe 2.04
  
• d3rilb1 appears in the current release, SCOPe 2.08