Lineage for d3rila1 (3ril A:1-77,A:432-497)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2066963Fold b.71: Glycosyl hydrolase domain [51010] (1 superfamily)
    folded sheet; greek-key
  4. 2066964Superfamily b.71.1: Glycosyl hydrolase domain [51011] (6 families) (S)
    this domain is C-terminal to the catalytic beta/alpha barrel domain
  5. 2067378Family b.71.1.2: Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [89388] (4 protein domains)
    interrupted by the catalytic domain; the C-terminal core is similar to the alpha-amylase domain
  6. 2067435Protein Glucosylceramidase [89389] (1 species)
    glycosyl hydrolase family 30; the N-terminal extension wraps around the C-terminal core
  7. 2067436Species Human (Homo sapiens) [TaxId:9606] [89390] (17 PDB entries)
  8. 2067461Domain d3rila1: 3ril A:1-77,A:432-497 [215846]
    Other proteins in same PDB: d3rila2, d3rilb2, d3rilc2, d3rild2
    automated match to d1ogsa1
    complexed with 3rk, nag, so4

Details for d3rila1

PDB Entry: 3ril (more details), 2.4 Å

PDB Description: The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
PDB Compounds: (A:) glucosylceramidase

SCOPe Domain Sequences for d3rila1:

Sequence; same for both SEQRES and ATOM records: (download)

>d3rila1 b.71.1.2 (A:1-77,A:432-497) Glucosylceramidase {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3rila1:

Click to download the PDB-style file with coordinates for d3rila1.
(The format of our PDB-style files is described here.)

Timeline for d3rila1: