SCOPe 2.08: Domain d3r8da_: 3r8d A:

Lineage for d3r8da_ (3r8d A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (32 PDB entries)

8. Domain d3r8da_: 3r8d A: [215657]
   automated match to d1nrla_
   complexed with pnu

Details for d3r8da_

PDB Entry: 3r8d, 2.8 Å

PDB Description: Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721

PDB Compounds: (A:) Nuclear receptor subfamily 1 group I member 2

SCOPe Domain Sequences for d3r8da_:

Sequence, based on SEQRES records:

>d3r8da_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgi

Sequence, based on observed residues (ATOM records):

>d3r8da_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgkwsqvrkdlcslkvslqlrgedgsv
wnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisllkgaafe
lcqlrfntvfnaetgtwecgrlsyclefqqlllepmlkfhymlkklqlheeeyvlmqais
lfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsinaqh
tqrllriqdihpfatplmqelfgi

Timeline for d3r8da_:

• d3r8da_ first appeared in SCOPe 2.03
  
• d3r8da_ appears in SCOPe 2.07