SCOPe 2.03: Domain d3r7oa_: 3r7o A:

Lineage for d3r7oa_ (3r7o A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (34 PDB entries)

8. Domain d3r7oa_: 3r7o A: [215651]
   automated match to d3dkga_
   complexed with m61

Details for d3r7oa_

PDB Entry: 3r7o, 2.3 Å

PDB Description: structure of dually phosphorylated c-met receptor kinase in complex with an mk-2461 analog

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3r7oa_:

Sequence, based on SEQRES records:

>d3r7oa_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdv
ntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfige
hhhhh

Sequence, based on observed residues (ATOM records):

>d3r7oa_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihc
avkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrn
firnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglar
dmydkeyysvhnklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfd
itvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehhhh
h

Timeline for d3r7oa_:

• d3r7oa_ is new in SCOPe 2.03-stable
  
• d3r7oa_ appears in SCOPe 2.04
  
• d3r7oa_ appears in the current release, SCOPe 2.08, called d3r7oa1