SCOPe 2.08: Domain d3qcvm1: 3qcv M:1-107

Lineage for d3qcvm1 (3qcv M:1-107)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (231 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d3qcvm1: 3qcv M:1-107 [215177]
   Other proteins in same PDB: d3qcvh_, d3qcvi_, d3qcvl2, d3qcvm2
   automated match to d1t66c1
   complexed with 18l

Details for d3qcvm1

PDB Entry: 3qcv, 2.51 Å

PDB Description: crystal structure of the lt3015 antibody fab fragment in complex with lysophosphatidic acid (18:2)

PDB Compounds: (M:) LT3015 antibody Fab fragment, light chain

SCOPe Domain Sequences for d3qcvm1:

Sequence; same for both SEQRES and ATOM records:

>d3qcvm1 b.1.1.1 (M:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
dvvmtqtplslpvtpgepasisctsgqslvhingntylhwylqkpgqspklliykvsnlf
sgvpdrfsgsgsgtdftlkisrveaedvgvyfcsqsthfpftfgqgtkleik

Timeline for d3qcvm1:

• d3qcvm1 first appeared in SCOPe 2.03
  
• d3qcvm1 appears in SCOPe 2.07