Lineage for d1mcoh2 (1mco H:118-219)

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2739517Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2739518Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2745637Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)
  6. 2747669Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)
  7. 2747676Species Human (Homo sapiens) [TaxId:9606] [88575] (173 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 2747942Domain d1mcoh2: 1mco H:118-219 [21469]
    Other proteins in same PDB: d1mcoh1, d1mcoh3, d1mcoh4, d1mcol1, d1mcol2
    part of intact antibody MCG

Details for d1mcoh2

PDB Entry: 1mco (more details), 3.2 Å

PDB Description: three-dimensional structure of a human immunoglobulin with a hinge deletion
PDB Compounds: (H:) igg1 mcg intact antibody (heavy chain)

SCOPe Domain Sequences for d1mcoh2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1mcoh2 b.1.1.2 (H:118-219) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpqpvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvapel

SCOPe Domain Coordinates for d1mcoh2:

Click to download the PDB-style file with coordinates for d1mcoh2.
(The format of our PDB-style files is described here.)

Timeline for d1mcoh2: