SCOPe 2.05: Domain d3orxe_: 3orx E:

Lineage for d3orxe_ (3orx E:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (21 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (615 PDB entries)

8. Domain d3orxe_: 3orx E: [214508]
   automated match to d4eopc_
   complexed with 1f8, cl; mutant

Details for d3orxe_

PDB Entry: 3orx, 2.2 Å

PDB Description: PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8

PDB Compounds: (E:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d3orxe_:

Sequence, based on SEQRES records:

>d3orxe_ d.144.1.0 (E:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyfcfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspellt
eksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvek
llvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d3orxe_ d.144.1.0 (E:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyfcfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksackssdl
walgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatkrl
gceemegygplkahpffesvtwenlhqqtppklt

Timeline for d3orxe_:

• d3orxe_ first appeared in SCOPe 2.03
  
• d3orxe_ appears in SCOPe 2.04
  
• d3orxe_ appears in SCOPe 2.06
  
• d3orxe_ appears in the current release, SCOPe 2.08