Lineage for d3oq1c1 (3oq1 C:24-289)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2426096Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2426097Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2426443Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2426470Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2426486Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845
  8. 2426561Domain d3oq1c1: 3oq1 C:24-289 [214476]
    Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
    automated match to d1xu9a_
    complexed with 3oq, nap

Details for d3oq1c1

PDB Entry: 3oq1 (more details), 2.6 Å

PDB Description: Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor
PDB Compounds: (C:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d3oq1c1:

Sequence; same for both SEQRES and ATOM records: (download)

>d3oq1c1 c.2.1.2 (C:24-289) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3oq1c1:

Click to download the PDB-style file with coordinates for d3oq1c1.
(The format of our PDB-style files is described here.)

Timeline for d3oq1c1: