SCOPe 2.03: Domain d3ooza_: 3ooz A:

Lineage for d3ooza_ (3ooz A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (229 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3ooza_: 3ooz A: [214452]
   automated match to d2zdza_
   complexed with zoo

Details for d3ooza_

PDB Entry: 3ooz, 1.8 Å

PDB Description: Bace1 in complex with the aminohydantoin Compound 102

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d3ooza_:

Sequence, based on SEQRES records:

>d3ooza_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgy

Sequence, based on observed residues (ATOM records):

>d3ooza_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgaevlasvggsmiiggidhslyt
gslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaav
ksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqy
lrpvdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsacdefrtaavegpfvt
ldmedcgy

Timeline for d3ooza_:

• d3ooza_ is new in SCOPe 2.03-stable
  
• d3ooza_ appears in SCOPe 2.04
  
• d3ooza_ appears in the current release, SCOPe 2.08