SCOPe 2.08: Domain d3nayb_: 3nay B:

Lineage for d3nayb_ (3nay B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d3nayb_: 3nay B: [213860]
   automated match to d1uu3a_
   complexed with mp6

Details for d3nayb_

PDB Entry: 3nay, 2.6 Å

PDB Description: pdk1 in complex with inhibitor mp6

PDB Compounds: (B:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d3nayb_:

Sequence, based on SEQRES records:

>d3nayb_ d.144.1.7 (B:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspellt
eksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvek
llvldatkrlgceemegygplkahpffesvtwenlhqqtppkltayl

Sequence, based on observed residues (ATOM records):

>d3nayb_ d.144.1.7 (B:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlsnsfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppkltayl

Timeline for d3nayb_:

• d3nayb_ first appeared in SCOPe 2.03
  
• d3nayb_ appears in SCOPe 2.07