SCOPe 2.06: Domain d3mxya1: 3mxy A:55-152

Lineage for d3mxya1 (3mxy A:55-152)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55564] (35 PDB entries)

8. Domain d3mxya1: 3mxy A:55-152 [213623]
   Other proteins in same PDB: d3mxya2
   automated match to d3n84b_

Details for d3mxya1

PDB Entry: 3mxy, 2.3 Å

PDB Description: Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.

PDB Compounds: (A:) Growth factor receptor-bound protein 2

SCOPe Domain Sequences for d3mxya1:

Sequence; same for both SEQRES and ATOM records:

>d3mxya1 d.93.1.1 (A:55-152) Growth factor receptor-bound protein 2 (GRB2) {Human (Homo sapiens) [TaxId: 9606]}
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdie

Timeline for d3mxya1:

• d3mxya1 first appeared in SCOPe 2.03, called d3mxya_
  
• d3mxya1 was called d3mxya_ in SCOPe 2.05
  
• d3mxya1 appears in the current release, SCOPe 2.07