SCOP 1.75: Domain d2f58l2: 2f58 L:108-212

Lineage for d2f58l2 (2f58 L:108-212)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [88567] (318 PDB entries)
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity
   SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region)
   Uniprot P01837 # KAC_MOUSE Ig kappa chain C region
   Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region
   SQ NA # part of Fab 28 against HIV-1 RT
   Uniprot P01837 #
   KAC_MOUSE Ig kappa chain C region
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region

8. Domain d2f58l2: 2f58 L:108-212 [21346]
   Other proteins in same PDB: d2f58h1, d2f58h2, d2f58l1
   part of anti-gp120 (HIV-1) Fab 58.2
   complexed with arn

Details for d2f58l2

PDB Entry: 2f58, 2.8 Å

PDB Description: igg1 fab fragment (58.2) complex with 12-residue cyclic peptide (including residues 315-324 of hiv-1 gp120) (mn isolate)

PDB Compounds: (L:) protein (igg1 fab 58.2 antibody (light chain))

SCOP Domain Sequences for d2f58l2:

Sequence; same for both SEQRES and ATOM records:

>d2f58l2 b.1.1.2 (L:108-212) Immunoglobulin light chain kappa constant domain, CL-kappa {Mouse (Mus musculus) [TaxId: 10090]}
radaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqd
skdstysmsstltltkdeyerhnsytceathktstspivksfnra

Timeline for d2f58l2:

• d2f58l2 first appeared (with stable ids) in SCOP 1.55
  
• d2f58l2 appears in SCOP 1.73
  
• d2f58l2 appears in SCOPe 2.01
  
• d2f58l2 appears in the current release, SCOPe 2.08