Lineage for d1cz8x2 (1cz8 X:108-213)

  1. Root: SCOP 1.73
  2. 651986Class b: All beta proteins [48724] (165 folds)
  3. 651987Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 651988Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 654118Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)
  6. 655938Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)
  7. 655939Species Human (Homo sapiens) [TaxId:9606] [88569] (125 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
  8. 656025Domain d1cz8x2: 1cz8 X:108-213 [21320]
    Other proteins in same PDB: d1cz8h1, d1cz8h2, d1cz8l1, d1cz8v_, d1cz8w_, d1cz8x1, d1cz8y1, d1cz8y2
    part of humanized Fab-12 neutralizing VEGF; affinity matured
    complexed with so4; mutant

Details for d1cz8x2

PDB Entry: 1cz8 (more details), 2.4 Å

PDB Description: vascular endothelial growth factor in complex with an affinity matured antibody
PDB Compounds: (X:) light chain of neutralizing antibody

SCOP Domain Sequences for d1cz8x2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1cz8x2 b.1.1.2 (X:108-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge

SCOP Domain Coordinates for d1cz8x2:

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Timeline for d1cz8x2: