SCOPe 2.01: Domain d1b4jl2: 1b4j L:108-214

Lineage for d1b4jl2 (1b4j L:108-214)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1b4jl2: 1b4j L:108-214 [21300]
   Other proteins in same PDB: d1b4jh1, d1b4jh2, d1b4jl1
   part of a chimeric anti-gamma-interferon Fab

Details for d1b4jl2

PDB Entry: 1b4j, 2.9 Å

PDB Description: comparison of the three-dimensional structures of a humanized and a chimeric fab of an anti-gamma-interferon antibody

PDB Compounds: (L:) antibody

SCOPe Domain Sequences for d1b4jl2:

Sequence; same for both SEQRES and ATOM records:

>d1b4jl2 b.1.1.2 (L:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1b4jl2:

• d1b4jl2 first appeared (with stable ids) in SCOP 1.55
  
• d1b4jl2 appears in SCOP 1.75
  
• d1b4jl2 appears in SCOPe 2.02
  
• d1b4jl2 appears in the current release, SCOPe 2.08