SCOP 1.65: Domain d1b2wl2: 1b2w L:108-214

Lineage for d1b2wl2 (1b2w L:108-214)

1. Root: SCOP 1.65

2. Class b: All beta proteins [48724] (126 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (22 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (62 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)

8. Domain d1b2wl2: 1b2w L:108-214 [21298]
   Other proteins in same PDB: d1b2wh1, d1b2wh2, d1b2wl1
   part of a humanized anti-gamma-interferon Fab

Details for d1b2wl2

PDB Entry: 1b2w, 2.9 Å

PDB Description: comparison of the three-dimensional structures of a humanized and a chimeric fab of an anti-gamma-interferon antibody

SCOP Domain Sequences for d1b2wl2:

Sequence; same for both SEQRES and ATOM records:

>d1b2wl2 b.1.1.2 (L:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens)}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1b2wl2:

• d1b2wl2 first appeared (with stable ids) in SCOP 1.55
  
• d1b2wl2 appears in SCOP 1.63
  
• d1b2wl2 appears in SCOP 1.67
  
• d1b2wl2 appears in the current release, SCOPe 2.08