SCOP 1.75: Domain d1a5fl2: 1a5f L:114-220

Lineage for d1a5fl2 (1a5f L:114-220)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [88567] (318 PDB entries)
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity
   SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region)
   Uniprot P01837 # KAC_MOUSE Ig kappa chain C region
   Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region
   SQ NA # part of Fab 28 against HIV-1 RT
   Uniprot P01837 #
   KAC_MOUSE Ig kappa chain C region
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region

8. Domain d1a5fl2: 1a5f L:114-220 [21294]
   Other proteins in same PDB: d1a5fh1, d1a5fh2, d1a5fl1
   part of an anti-E-selectin Fab

Details for d1a5fl2

PDB Entry: 1a5f, 2.8 Å

PDB Description: fab fragment of a monoclonal anti-e-selectin antibody

PDB Compounds: (L:) monoclonal anti-e-selectin 7a9 antibody (light chain)

SCOP Domain Sequences for d1a5fl2:

Sequence; same for both SEQRES and ATOM records:

>d1a5fl2 b.1.1.2 (L:114-220) Immunoglobulin light chain kappa constant domain, CL-kappa {Mouse (Mus musculus) [TaxId: 10090]}
radaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqd
skdstysmsstltltkdeyerhnsytceathktstspivksfnrnec

Timeline for d1a5fl2:

• d1a5fl2 first appeared (with stable ids) in SCOP 1.55
  
• d1a5fl2 appears in SCOP 1.73
  
• d1a5fl2 appears in SCOPe 2.01
  
• d1a5fl2 appears in the current release, SCOPe 2.08