SCOPe 2.08: Domain d1a4kh2: 1a4k H:120-211

Lineage for d1a4kh2 (1a4k H:120-211)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (173 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d1a4kh2: 1a4k H:120-211 [21247]
   Other proteins in same PDB: d1a4ka1, d1a4ka2, d1a4kb1, d1a4kh1, d1a4kl1, d1a4kl2
   part of humanized Diels-Alder catalytic Fab
   complexed with cd, fra

Details for d1a4kh2

PDB Entry: 1a4k, 2.4 Å

PDB Description: diels alder catalytic antibody with transition state analogue

PDB Compounds: (H:) antibody fab

SCOPe Domain Sequences for d1a4kh2:

Sequence; same for both SEQRES and ATOM records:

>d1a4kh2 b.1.1.2 (H:120-211) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
svfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkkv

Timeline for d1a4kh2:

• d1a4kh2 first appeared (with stable ids) in SCOP 1.55
  
• d1a4kh2 appears in SCOPe 2.07