SCOPe 2.08: Domain d3km0a_: 3km0 A:

Lineage for d3km0a_ (3km0 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
   Uniprot P14061

8. Domain d3km0a_: 3km0 A: [212415]
   automated match to d1jtva_
   complexed with aom, nap

Details for d3km0a_

PDB Entry: 3km0, 2.3 Å

PDB Description: 17betaHSD1 in complex with 3beta-diol

PDB Compounds: (A:) Estradiol 17-beta-dehydrogenase 1

SCOPe Domain Sequences for d3km0a_:

Sequence, based on SEQRES records:

>d3km0a_ c.2.1.2 (A:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevf

Sequence, based on observed residues (ATOM records):

>d3km0a_ c.2.1.2 (A:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtagspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalra
pkptlryftterflpllrmrlddpsgsnyvtamhrevf

Timeline for d3km0a_:

• d3km0a_ first appeared in SCOPe 2.03
  
• d3km0a_ appears in SCOPe 2.07