SCOPe 2.05: Domain d3klpx_: 3klp X:

Lineage for d3klpx_ (3klp X:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
   Uniprot P14061

8. Domain d3klpx_: 3klp X: [212414]
   automated match to d1jtva_
   complexed with b81

Details for d3klpx_

PDB Entry: 3klp, 2.5 Å

PDB Description: 17beta-HSD1 in complex with A-diol

PDB Compounds: (X:) Estradiol 17-beta-dehydrogenase 1

SCOPe Domain Sequences for d3klpx_:

Sequence, based on SEQRES records:

>d3klpx_ c.2.1.2 (X:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfg

Sequence, based on observed residues (ATOM records):

>d3klpx_ c.2.1.2 (X:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalrapkp
tlryftterflpllrmrlddpsgsnyvtamhrevfg

Timeline for d3klpx_:

• d3klpx_ first appeared in SCOPe 2.03
  
• d3klpx_ appears in SCOPe 2.04
  
• d3klpx_ appears in SCOPe 2.06
  
• d3klpx_ appears in the current release, SCOPe 2.08