SCOPe 2.06: Domain d3irxa2: 3irx A:430-554

Lineage for d3irxa2 (3irx A:430-554)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (15 families)
   consists of one domain of this fold

5. Family c.55.3.0: automated matches [191357] (1 protein)
   not a true family

6. Protein automated matches [190396] (35 species)
   not a true protein

7. Species Human immunodeficiency virus type 1 bh10 [TaxId:11678] [225195] (20 PDB entries)

8. Domain d3irxa2: 3irx A:430-554 [211860]
   Other proteins in same PDB: d3irxa1, d3irxa3, d3irxb_
   automated match to d1bqna1
   protein/DNA complex; protein/RNA complex; complexed with udr

Details for d3irxa2

PDB Entry: 3irx, 2.8 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase (rt) in complex with the non-nucleoside rt inhibitor (e)-s-methyl 5-(1-(3,7-dimethyl-2- oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2- yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.

PDB Compounds: (A:) Reverse transcriptase/ribonuclease H

SCOPe Domain Sequences for d3irxa2:

Sequence; same for both SEQRES and ATOM records:

>d3irxa2 c.55.3.0 (A:430-554) automated matches {Human immunodeficiency virus type 1 bh10 [TaxId: 11678]}
ekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqds
glevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvd
klvsa

Timeline for d3irxa2:

• d3irxa2 first appeared in SCOPe 2.03
  
• d3irxa2 appears in SCOPe 2.05
  
• d3irxa2 appears in SCOPe 2.07
  
• d3irxa2 appears in the current release, SCOPe 2.08