SCOPe 2.05: Domain d3iopa_: 3iop A:

Lineage for d3iopa_ (3iop A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d3iopa_: 3iop A: [211834]
   automated match to d4eopc_
   complexed with 8i1

Details for d3iopa_

PDB Entry: 3iop, 2.2 Å

PDB Description: PDK-1 in complex with the inhibitor Compound-8i

PDB Compounds: (A:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d3iopa_:

Sequence, based on SEQRES records:

>d3iopa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspell
teksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlve
kllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d3iopa_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlssfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d3iopa_:

• d3iopa_ first appeared in SCOPe 2.03
  
• d3iopa_ appears in SCOPe 2.04
  
• d3iopa_ appears in SCOPe 2.06
  
• d3iopa_ appears in the current release, SCOPe 2.08