SCOPe 2.08: Domain d3ibea4: 3ibe A:726-1092

Lineage for d3ibea4 (3ibe A:726-1092)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d3ibea4: 3ibe A:726-1092 [211568]
   Other proteins in same PDB: d3ibea1, d3ibea2, d3ibea3, d3ibea5
   automated match to d1e8ya4
   complexed with l64, so4

Details for d3ibea4

PDB Entry: 3ibe, 2.8 Å

PDB Description: crystal structure of a pyrazolopyrimidine inhibitor bound to pi3 kinase gamma

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3ibea4:

Sequence, based on SEQRES records:

>d3ibea4 d.144.1.4 (A:726-1092) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlvl

Sequence, based on observed residues (ATOM records):

>d3ibea4 d.144.1.4 (A:726-1092) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghke
rvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpl
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl

Timeline for d3ibea4:

• d3ibea4 first appeared in SCOPe 2.03
  
• d3ibea4 appears in SCOPe 2.07