SCOPe 2.08: Domain d3ibea2: 3ibe A:357-522

Lineage for d3ibea2 (3ibe A:357-522)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (4 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (70 PDB entries)

8. Domain d3ibea2: 3ibe A:357-522 [211566]
   Other proteins in same PDB: d3ibea1, d3ibea3, d3ibea4, d3ibea5
   automated match to d1e8ya2
   complexed with l64, so4

Details for d3ibea2

PDB Entry: 3ibe, 2.8 Å

PDB Description: crystal structure of a pyrazolopyrimidine inhibitor bound to pi3 kinase gamma

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3ibea2:

Sequence, based on SEQRES records:

>d3ibea2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkapalsskasaespsseskgkvrllyyvnlllidhrfllr
rgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d3ibea2 b.7.1.1 (A:357-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
cdrkfrvkirgidipvldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsiki
kdlpkgallnlqiycgvrllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnp
dkensmsisilldn

Timeline for d3ibea2:

• d3ibea2 first appeared in SCOPe 2.03
  
• d3ibea2 appears in SCOPe 2.07