SCOP 1.71: Domain d2rcsl2: 2rcs L:110-214

Lineage for d2rcsl2 (2rcs L:110-214)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (100 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)

8. Domain d2rcsl2: 2rcs L:110-214 [21118]
   Other proteins in same PDB: d2rcsh1, d2rcsh2, d2rcsl1
   part of humanized Fab 48G7

Details for d2rcsl2

PDB Entry: 2rcs, 2.1 Å

PDB Description: immunoglobulin 48g7 germline fab-affinity maturation of an esterolytic antibody

SCOP Domain Sequences for d2rcsl2:

Sequence; same for both SEQRES and ATOM records:

>d2rcsl2 b.1.1.2 (L:110-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens)}
vaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdsk
dstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d2rcsl2:

• d2rcsl2 first appeared (with stable ids) in SCOP 1.55
  
• d2rcsl2 appears in SCOP 1.69
  
• d2rcsl2 appears in SCOP 1.73
  
• d2rcsl2 appears in the current release, SCOPe 2.08