Lineage for d1aj7h2 (1aj7 H:115-216)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2020524Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)
  6. 2022294Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 2022298Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 2022355Domain d1aj7h2: 1aj7 H:115-216 [21117]
    Other proteins in same PDB: d1aj7h1, d1aj7l1, d1aj7l2
    part of humanized Fab 48G7
    complexed with npe

Details for d1aj7h2

PDB Entry: 1aj7 (more details), 2.1 Å

PDB Description: immunoglobulin 48g7 germline fab antibody complexed with hapten 5-(para-nitrophenyl phosphonate)-pentanoic acid. affinity maturation of an esterolytic antibody
PDB Compounds: (H:) immunoglobulin 48g7 fab (heavy chain)

SCOPe Domain Sequences for d1aj7h2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1aj7h2 b.1.1.2 (H:115-216) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1aj7h2:

Click to download the PDB-style file with coordinates for d1aj7h2.
(The format of our PDB-style files is described here.)

Timeline for d1aj7h2:

View in 3D
Domains from same chain:
(mouse over for more information)