SCOPe 2.06: Domain d3hb4x_: 3hb4 X:

Lineage for d3hb4x_ (3hb4 X:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
   Uniprot P14061

8. Domain d3hb4x_: 3hb4 X: [210960]
   automated match to d1jtva_
   complexed with e2b

Details for d3hb4x_

PDB Entry: 3hb4, 2.21 Å

PDB Description: 17beta-hydroxysteroid dehydrogenase type1 complexed with e2b

PDB Compounds: (X:) Estradiol 17-beta-dehydrogenase 1

SCOPe Domain Sequences for d3hb4x_:

Sequence; same for both SEQRES and ATOM records:

>d3hb4x_ c.2.1.2 (X:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevf

Timeline for d3hb4x_:

• d3hb4x_ first appeared in SCOPe 2.03
  
• d3hb4x_ appears in SCOPe 2.05
  
• d3hb4x_ appears in SCOPe 2.07
  
• d3hb4x_ appears in the current release, SCOPe 2.08