SCOPe 2.08: Domain d3fstc_: 3fst C:

Lineage for d3fstc_ (3fst C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein automated matches [193645] (4 species)
   not a true protein

7. Species Escherichia coli K-12 [TaxId:83333] [225710] (2 PDB entries)

8. Domain d3fstc_: 3fst C: [210088]
   automated match to d1b5tb_
   complexed with fad, mry, so4; mutant

Details for d3fstc_

PDB Entry: 3fst, 1.65 Å

PDB Description: crystal structure of escherichia coli methylenetetrahydrofolate reductase mutant phe223leu at ph 7.4

PDB Compounds: (C:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d3fstc_:

Sequence, based on SEQRES records:

>d3fstc_ c.1.23.1 (C:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppgsgkpemyasdlvtllke
vadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsa
gidveiipgilpvsnfkqakkladmtnvripawmaqmfdgldddaetrklvganiamdmv
kilsregvkdfhfytlnraemsyaichtlgvrp

Sequence, based on observed residues (ATOM records):

>d3fstc_ c.1.23.1 (C:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdemyasdlvtllkevadfdisv
aaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsagidveiip
gilpvsnfkqakkladmtnvripawmaqmfdgldddaetrklvganiamdmvkilsregv
kdfhfytlnraemsyaichtlgvrp

Timeline for d3fstc_:

• d3fstc_ first appeared in SCOPe 2.03
  
• d3fstc_ appears in SCOPe 2.07