Lineage for d1fved2 (1fve D:121-223)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2020524Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)
  6. 2022294Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 2022298Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 2022448Domain d1fved2: 1fve D:121-223 [20969]
    Other proteins in same PDB: d1fvea1, d1fvea2, d1fveb1, d1fvec1, d1fvec2, d1fved1
    part of humanized Fab 4D5, herceptin

Details for d1fved2

PDB Entry: 1fve (more details), 2.7 Å

PDB Description: x-ray structures of the antigen-binding domains from three variants of humanized anti-p185-her2 antibody 4d5 and comparison with molecular modeling
PDB Compounds: (D:) igg1-kappa 4d5 fab (heavy chain)

SCOPe Domain Sequences for d1fved2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1fved2 b.1.1.2 (D:121-223) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1fved2:

Click to download the PDB-style file with coordinates for d1fved2.
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Timeline for d1fved2: