SCOP 1.75: Domain d1fvea2: 1fve A:108-214

Lineage for d1fvea2 (1fve A:108-214)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
   SQ NA # humanized antibody
   Uniprot P01834 # KAC_HUMAN Ig kappa chain C region
   SQ P01834 # KAC_HUMAN Ig kappa chain C region.
   SQ NA # engineered antibody
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1fvea2: 1fve A:108-214 [20966]
   Other proteins in same PDB: d1fvea1, d1fveb1, d1fveb2, d1fvec1, d1fved1, d1fved2
   part of humanized Fab 4D5, herceptin

Details for d1fvea2

PDB Entry: 1fve, 2.7 Å

PDB Description: x-ray structures of the antigen-binding domains from three variants of humanized anti-p185-her2 antibody 4d5 and comparison with molecular modeling

PDB Compounds: (A:) igg1-kappa 4d5 fab (light chain)

SCOP Domain Sequences for d1fvea2:

Sequence; same for both SEQRES and ATOM records:

>d1fvea2 b.1.1.2 (A:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1fvea2:

• d1fvea2 first appeared (with stable ids) in SCOP 1.55
  
• d1fvea2 appears in SCOP 1.73
  
• d1fvea2 appears in SCOPe 2.01
  
• d1fvea2 appears in the current release, SCOPe 2.08