Lineage for d3ehix_ (3ehi X:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2972108Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2972109Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2972110Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2972208Protein Thymidylate synthase [55833] (7 species)
  7. 2972355Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)
  8. 2972382Domain d3ehix_: 3ehi X: [209503]
    automated match to d2aaza_
    complexed with edo, so4

Details for d3ehix_

PDB Entry: 3ehi (more details), 2 Å

PDB Description: crystal structure of human thymidyalte synthase m190k with loop 181- 197 stabilized in the inactive conformation
PDB Compounds: (X:) Thymidylate synthase

SCOPe Domain Sequences for d3ehix_:

Sequence, based on SEQRES records: (download)

>d3ehix_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplkalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikme

Sequence, based on observed residues (ATOM records): (download)

>d3ehix_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelssdfldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqg
vdqlqrvidtiktnpddrriimcawnprdlplkalppchalcqfyvvnselscqlyqrsg
dmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfp
klrilrkvekiddfkaedfqiegynphptikme

SCOPe Domain Coordinates for d3ehix_:

Click to download the PDB-style file with coordinates for d3ehix_.
(The format of our PDB-style files is described here.)

Timeline for d3ehix_: