Lineage for d3egyx_ (3egy X:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2578667Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2578668Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2578669Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2578767Protein Thymidylate synthase [55833] (7 species)
  7. 2578916Species Human (Homo sapiens) [TaxId:9606] [55840] (42 PDB entries)
  8. 2578947Domain d3egyx_: 3egy X: [209502]
    automated match to d2aaza_
    complexed with edo, so4

Details for d3egyx_

PDB Entry: 3egy (more details), 2.18 Å

PDB Description: crystal structure of human thymidyalte synthase a191k with loop 181- 197 stabilized in the inactive conformation
PDB Compounds: (X:) Thymidylate synthase

SCOPe Domain Sequences for d3egyx_:

Sequence, based on SEQRES records: (download)

>d3egyx_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmklppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records): (download)

>d3egyx_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstvygfqwrhfggvdqlqrvidtiktnpddrriimcawnprdlplmklppc
halcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgda
hiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

SCOPe Domain Coordinates for d3egyx_:

Click to download the PDB-style file with coordinates for d3egyx_.
(The format of our PDB-style files is described here.)

Timeline for d3egyx_: