SCOPe 2.05: Domain d3egyx_: 3egy X:

Lineage for d3egyx_ (3egy X:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (24 PDB entries)

8. Domain d3egyx_: 3egy X: [209502]
   automated match to d2aaza_
   complexed with edo, so4

Details for d3egyx_

PDB Entry: 3egy, 2.18 Å

PDB Description: crystal structure of human thymidyalte synthase a191k with loop 181- 197 stabilized in the inactive conformation

PDB Compounds: (X:) Thymidylate synthase

SCOPe Domain Sequences for d3egyx_:

Sequence, based on SEQRES records:

>d3egyx_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmklppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records):

>d3egyx_ d.117.1.1 (X:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstvygfqwrhfggvdqlqrvidtiktnpddrriimcawnprdlplmklppc
halcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgda
hiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Timeline for d3egyx_:

• d3egyx_ first appeared in SCOPe 2.03
  
• d3egyx_ appears in SCOPe 2.04
  
• d3egyx_ appears in SCOPe 2.06
  
• d3egyx_ appears in the current release, SCOPe 2.08