SCOPe 2.03: Domain d3d4qa_: 3d4q A:

Lineage for d3d4qa_ (3d4q A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d3d4qa_: 3d4q A: [208997]
   automated match to d1i44a_
   complexed with sm5

Details for d3d4qa_

PDB Entry: 3d4q, 2.8 Å

PDB Description: pyrazole-based inhibitors of b-raf kinase

PDB Compounds: (A:) B-Raf proto-oncogene serine/threonine-protein kinase

SCOPe Domain Sequences for d3d4qa_:

Sequence, based on SEQRES records:

>d3d4qa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirm
qdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpk
amkrlmaeclkkkrderplfpqilasiellarslpk

Sequence, based on observed residues (ATOM records):

>d3d4qa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvlsgsilwmapevirmqdknpysfqsdv
yafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkk
krderplfpqilasiellarslpk

Timeline for d3d4qa_:

• d3d4qa_ is new in SCOPe 2.03-stable
  
• d3d4qa_ appears in SCOPe 2.04
  
• d3d4qa_ appears in the current release, SCOPe 2.08