SCOPe 2.03: Domain d3cp6a_: 3cp6 A:

Lineage for d3cp6a_ (3cp6 A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (34 PDB entries)

8. Domain d3cp6a_: 3cp6 A: [208920]
   automated match to d2f89f_
   complexed with mg, rsx; mutant

Details for d3cp6a_

PDB Entry: 3cp6, 1.95 Å

PDB Description: crystal structure of human farnesyl diphosphate synthase (t201a mutant) complexed with mg and biphosphonate inhibitor

PDB Compounds: (A:) Farnesyl pyrophosphate synthetase

SCOPe Domain Sequences for d3cp6a_:

Sequence, based on SEQRES records:

>d3cp6a_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvvafre
lveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldain
danlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrfte
kryksivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfg
dpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldl
pavflqyeedsyshimalieqyaaplppavflglarki

Sequence, based on observed residues (ATOM records):

>d3cp6a_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
aqekqdfvqhfsqivrvltehpeigdaiarlkevleynaiggkynrgltvvvafrelvep
rkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaindanl
leaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekryk
sivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdpsv
tgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpavf
lqyeedsyshimalieqyaaplppavflglarki

Timeline for d3cp6a_:

• d3cp6a_ is new in SCOPe 2.03-stable
  
• d3cp6a_ appears in SCOPe 2.04
  
• d3cp6a_ appears in the current release, SCOPe 2.08