SCOPe 2.03: Domain d3bmca_: 3bmc A:

Lineage for d3bmca_ (3bmc A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)

7. Species Trypanosoma brucei [TaxId:5702] [226783] (7 PDB entries)

8. Domain d3bmca_: 3bmc A: [208663]
   automated match to d1p33a_
   complexed with fol, nap

Details for d3bmca_

PDB Entry: 3bmc, 2.6 Å

PDB Description: Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and substrate (folate)

PDB Compounds: (A:) pteridine reductase

SCOPe Domain Sequences for d3bmca_:

Sequence, based on SEQRES records:

>d3bmca_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqva
eligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhal
vgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadav
iflvsgsaqyitgsiikvdgglslvha

Sequence, based on observed residues (ATOM records):

>d3bmca_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqsnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygirv
ngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsiikv
dgglslvha

Timeline for d3bmca_:

• d3bmca_ is new in SCOPe 2.03-stable
  
• d3bmca_ appears in SCOPe 2.04
  
• d3bmca_ appears in the current release, SCOPe 2.08