SCOPe 2.03: Domain d2xp2a_: 2xp2 A:

Lineage for d2xp2a_ (2xp2 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d2xp2a_: 2xp2 A: [207290]
   automated match to d3gqla_
   complexed with vgh

Details for d2xp2a_

PDB Entry: 2xp2, 1.9 Å

PDB Description: structure of the human anaplastic lymphoma kinase in complex with crizotinib (pf-02341066)

PDB Compounds: (A:) tyrosine-protein kinase receptor

SCOPe Domain Sequences for d2xp2a_:

Sequence, based on SEQRES records:

>d2xp2a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpiey

Sequence, based on observed residues (ATOM records):

>d2xp2a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglgafgevyegqvsplqvavktlpevcseqde
ldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyramlp
vkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppk
ncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey

Timeline for d2xp2a_:

• d2xp2a_ is new in SCOPe 2.03-stable
  
• d2xp2a_ appears in SCOPe 2.04
  
• d2xp2a_ appears in the current release, SCOPe 2.08