Lineage for d2wrma_ (2wrm A:)

  1. Root: SCOPe 2.08
  2. 3012399Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)
  3. 3016464Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 3016465Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 3017418Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)
  6. 3017426Protein Viral RNA polymerase [56695] (17 species)
  7. 3017476Species Hepatitis C virus [TaxId:11103] [56697] (72 PDB entries)
  8. 3017504Domain d2wrma_: 2wrm A: [206983]
    automated match to d1gx5a_
    complexed with qq3

Details for d2wrma_

PDB Entry: 2wrm (more details), 1.95 Å

PDB Description: identification of novel allosteric inhibitors of hepatitis c virus ns5b polymerase thumb domain (site ii) by structure-based design
PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2wrma_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2wrma_ e.8.1.4 (A:) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk

SCOPe Domain Coordinates for d2wrma_:

Click to download the PDB-style file with coordinates for d2wrma_.
(The format of our PDB-style files is described here.)

Timeline for d2wrma_: