SCOPe 2.08: Domain d2wcxa_: 2wcx A:

Lineage for d2wcxa_ (2wcx A:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (25 species)
   not a true protein

7. Species Hepatitis C virus genotype 1b (isolate bk) [TaxId:11105] [188687] (17 PDB entries)

8. Domain d2wcxa_: 2wcx A: [206770]
   automated match to d4e78a_
   protein/RNA complex; complexed with mn, vgc

Details for d2wcxa_

PDB Entry: 2wcx, 2 Å

PDB Description: crystal structure of hepatitis c virus ns5b polymerase in complex with thienopyrrole-based finger-loop inhibitors

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d2wcxa_:

Sequence, based on SEQRES records:

>d2wcxa_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk

Sequence, based on observed residues (ATOM records):

>d2wcxa_ e.8.1.4 (A:) automated matches {Hepatitis C virus genotype 1b (isolate bk) [TaxId: 11105]}
smsytwtgalitpcaaeesklmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkak
astvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpi
dttimaknevfcvgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgq
rveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslter
lyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngdd
lvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgk
rvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeql
ekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrv
wrhrarsvrarllsqggraatcgkylfnwavk

Timeline for d2wcxa_:

• d2wcxa_ first appeared in SCOPe 2.03
  
• d2wcxa_ appears in SCOPe 2.07