SCOPe 2.05: Domain d2v4la3: 2v4l A:525-725

Lineage for d2v4la3 (2v4l A:525-725)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (24 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (26 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (58 PDB entries)

8. Domain d2v4la3: 2v4l A:525-725 [206205]
   Other proteins in same PDB: d2v4la1, d2v4la2, d2v4la4
   automated match to d1e8ya1
   complexed with abj

Details for d2v4la3

PDB Entry: 2v4l, 2.5 Å

PDB Description: complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d2v4la3:

Sequence, based on SEQRES records:

>d2v4la3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
hpialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslk
hpkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraia
vqklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseia
qsrhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d2v4la3 a.118.1.6 (A:525-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
hpiaraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwg
qqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhy
llqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavilea
ylrgcg

Timeline for d2v4la3:

• d2v4la3 first appeared in SCOPe 2.03
  
• d2v4la3 appears in SCOPe 2.04
  
• d2v4la3 appears in SCOPe 2.06
  
• d2v4la3 appears in the current release, SCOPe 2.08