SCOPe 2.06: Domain d2rd8b_: 2rd8 B:

Lineage for d2rd8b_ (2rd8 B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (26 PDB entries)

8. Domain d2rd8b_: 2rd8 B: [206085]
   automated match to d2aaza_
   complexed with bme, po4; mutant

Details for d2rd8b_

PDB Entry: 2rd8, 2.5 Å

PDB Description: human thymidylate synthase stabilized in active conformation by r163k mutation: asymmetry and reactivity of cys195

PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d2rd8b_:

Sequence, based on SEQRES records:

>d2rd8b_ d.117.1.1 (B:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records):

>d2rd8b_ d.117.1.1 (B:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Timeline for d2rd8b_:

• d2rd8b_ first appeared in SCOPe 2.03
  
• d2rd8b_ appears in SCOPe 2.05
  
• d2rd8b_ appears in SCOPe 2.07
  
• d2rd8b_ appears in the current release, SCOPe 2.08