Lineage for d2rd8b_ (2rd8 B:)

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1428979Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 1428980Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 1428981Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 1429014Protein Thymidylate synthase [55833] (7 species)
  7. 1429147Species Human (Homo sapiens) [TaxId:9606] [55840] (12 PDB entries)
  8. 1429161Domain d2rd8b_: 2rd8 B: [206085]
    automated match to d2aaza_
    complexed with bme, po4; mutant

Details for d2rd8b_

PDB Entry: 2rd8 (more details), 2.5 Å

PDB Description: human thymidylate synthase stabilized in active conformation by r163k mutation: asymmetry and reactivity of cys195
PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d2rd8b_:

Sequence, based on SEQRES records: (download)

>d2rd8b_ d.117.1.1 (B:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records): (download)

>d2rd8b_ d.117.1.1 (B:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

SCOPe Domain Coordinates for d2rd8b_:

Click to download the PDB-style file with coordinates for d2rd8b_.
(The format of our PDB-style files is described here.)

Timeline for d2rd8b_: