SCOPe 2.08: Domain d2r4bb_: 2r4b B:

Lineage for d2r4bb_ (2r4b B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d2r4bb_: 2r4b B: [205964]
   automated match to d1p4ob_
   complexed with gw7

Details for d2r4bb_

PDB Entry: 2r4b, 2.4 Å

PDB Description: ErbB4 kinase domain complexed with a thienopyrimidine inhibitor

PDB Compounds: (B:) Receptor tyrosine-protein kinase erbB-4

SCOPe Domain Sequences for d2r4bb_:

Sequence, based on SEQRES records:

>d2r4bb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwvpegetvkipvaikil
nettgpkanvefmdealimasmdhphlvrllgvclsptiqlvtqlmphgclleyvhehkd
nigsqlllnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvkitdfglarllegdek
eynadggkmpikwmalecihyrkfthqsdvwsygvtiwelmtfggkpydgiptreipdll
ekgerlpqppictidvymvmvkcwmidadsrpkfkelaaefsrmardpqrylviqgdd

Sequence, based on observed residues (ATOM records):

>d2r4bb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwvpegetvkipvaikil
anvefmdealimasmdhphlvrllgvclsptiqlvtqlmphgclleyvhehkdnigsqll
lnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvkitdfglarllegdekeynadgg
kmpikwmalecihyrkfthqsdvwsygvtiwelmtfggkpydgiptreipdllekgerlp
qppictidvymvmvkcwmidadsrpkfkelaaefsrmardpqrylviqgdd

Timeline for d2r4bb_:

• d2r4bb_ first appeared in SCOPe 2.03
  
• d2r4bb_ appears in SCOPe 2.07