SCOPe 2.08: Domain d2r3vb1: 2r3v B:2-225

Lineage for d2r3vb1 (2r3v B:2-225)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.14: Ribosomal protein S5 domain 2-like [54210] (1 superfamily)
   core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover

4. Superfamily d.14.1: Ribosomal protein S5 domain 2-like [54211] (13 families)

5. Family d.14.1.5: GHMP Kinase, N-terminal domain [54232] (7 proteins)

6. Protein Mevalonate kinase [75353] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [225475] (1 PDB entry)

8. Domain d2r3vb1: 2r3v B:2-225 [205957]
   Other proteins in same PDB: d2r3va2, d2r3vb2, d2r3vc2, d2r3vd2
   automated match to d1kvka1

Details for d2r3vb1

PDB Entry: 2r3v, 2.5 Å

PDB Description: The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

PDB Compounds: (B:) Mevalonate Kinase

SCOPe Domain Sequences for d2r3vb1:

Sequence, based on SEQRES records:

>d2r3vb1 d.14.1.5 (B:2-225) Mevalonate kinase {Human (Homo sapiens) [TaxId: 9606]}
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsfleqgdvttptseqveklkevaglpddcavterlavlaflylylsicr
kqralpsldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtked
lelinkwafqgermihgnpsgvdnavstwggalryhqgkisslk

Sequence, based on observed residues (ATOM records):

>d2r3vb1 d.14.1.5 (B:2-225) Mevalonate kinase {Human (Homo sapiens) [TaxId: 9606]}
lsevllvsapgkvilhgehavvhgkvalavslnlrtflrlqphsngkvdlslpnigikra
wdvarlqsldtsfttptseqveklkevaglpddcavterlavlaflylylsicrkqralp
sldivvwselppgaglgssaaysvclaaalltvceeipnplkdgdcvnrwtkedlelink
wafqgermihgnpsgvdnavstwggalryhqgkisslk

Timeline for d2r3vb1:

• d2r3vb1 first appeared in SCOPe 2.03
  
• d2r3vb1 appears in SCOPe 2.07