SCOPe 2.08: Domain d2r2hb1: 2r2h B:1-111

Lineage for d2r2hb1 (2r2h B:1-111)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (68 PDB entries)
   Uniprot P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4

8. Domain d2r2hb1: 2r2h B:1-111 [205952]
   Other proteins in same PDB: d2r2ha1, d2r2ha2, d2r2hb2
   automated match to d3t65b1
   complexed with ko2, mg, zn

Details for d2r2hb1

PDB Entry: 2r2h, 2 Å

PDB Description: structure of s25-2 in complex with ko

PDB Compounds: (B:) Fab, antibody fragment (IgG1k), heavy chain

SCOPe Domain Sequences for d2r2hb1:

Sequence; same for both SEQRES and ATOM records:

>d2r2hb1 b.1.1.1 (B:1-111) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evklvesggglvqsggslrlscatsgftftdyymswvrqppgkalewlgfirnkangytt
eyspsvkgrftisrdnsqsilylqmntlraedsatyycardhdgyyerfsywgqgtlvtv
sa

Timeline for d2r2hb1:

• d2r2hb1 first appeared in SCOPe 2.03
  
• d2r2hb1 appears in SCOPe 2.07