SCOPe 2.04: Domain d2pzyc_: 2pzy C:

Lineage for d2pzyc_ (2pzy C:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (14 PDB entries)

8. Domain d2pzyc_: 2pzy C: [205711]
   automated match to d1nxkc_
   complexed with b18, stu

Details for d2pzyc_

PDB Entry: 2pzy, 2.9 Å

PDB Description: Structure of MK2 Complexed with Compound 76

PDB Compounds: (C:) MAP kinase-activated protein kinase 2

SCOPe Domain Sequences for d2pzyc_:

Sequence, based on SEQRES records:

>d2pzyc_ d.144.1.7 (C:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
qfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpka
rrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafter
easeimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslt
tpcytpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirm
gqyefpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrv
lkedkerwedvkeemtsa

Sequence, based on observed residues (ATOM records):

>d2pzyc_ d.144.1.7 (C:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
qfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpka
rrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafter
easeimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettpyyvap
evlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpews
evseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedv
keemtsa

Timeline for d2pzyc_:

• d2pzyc_ first appeared in SCOPe 2.03
  
• d2pzyc_ appears in SCOPe 2.05
  
• d2pzyc_ appears in the current release, SCOPe 2.08