SCOPe 2.03: Domain d2hwob_: 2hwo B:

Lineage for d2hwob_ (2hwo B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-src tyrosine kinase [56155] (2 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Chicken (Gallus gallus) [TaxId:9031] [56157] (37 PDB entries)

8. Domain d2hwob_: 2hwo B: [204652]
   automated match to d2gqgb_
   complexed with gol, rbs

Details for d2hwob_

PDB Entry: 2hwo, 2.5 Å

PDB Description: crystal structure of src kinase domain in complex with covalent inhibitor

PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d2hwob_:

Sequence, based on SEQRES records:

>d2hwob_ d.144.1.7 (B:) c-src tyrosine kinase {Chicken (Gallus gallus) [TaxId: 9031]}
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaalyg
rftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcq
cwrkdpeerptfeylqafledyftstepqyqpgenl

Sequence, based on observed residues (ATOM records):

>d2hwob_ d.144.1.7 (B:) c-src tyrosine kinase {Chicken (Gallus gallus) [TaxId: 9031]}
daweipreslrlevklgqggevwmgtwngttrvaiktlkqvmkklrheklvqlyavvsee
piyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraani
lvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrev
ldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpge
nl

Timeline for d2hwob_:

• d2hwob_ is new in SCOPe 2.03-stable
  
• d2hwob_ appears in SCOPe 2.04
  
• d2hwob_ appears in the current release, SCOPe 2.08