Lineage for d1qfwh_ (1qfw H:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2017323Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2017824Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (181 PDB entries)
    Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor
  8. 2018040Domain d1qfwh_: 1qfw H: [20435]
    Other proteins in same PDB: d1qfwa_, d1qfwb_, d1qfwl_, d1qfwm_
    part of anti-[gonadotropin alpha subunit] Fv
    complexed with nag

Details for d1qfwh_

PDB Entry: 1qfw (more details), 3.5 Å

PDB Description: ternary complex of human chorionic gonadotropin with fv anti alpha subunit and fv anti beta subunit
PDB Compounds: (H:) antibody (anti alpha subunit) (heavy chain)

SCOPe Domain Sequences for d1qfwh_:

Sequence, based on SEQRES records: (download)

>d1qfwh_ b.1.1.1 (H:) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qlqqsgaelvkpgasvklsckasdytftsywmhwvkqrpgqglewigeinptngrtyyne
kfkskatltvaasastaamqassltsedsavyycarrygnsfdywgqgttvtvss

Sequence, based on observed residues (ATOM records): (download)

>d1qfwh_ b.1.1.1 (H:) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qlqqsgaelvkpgasvklsckasdytftsywmhwvkqrpgqglewigeinptngrtyyne
kkatltvaasastaamqassltsedsavyycarrygnsfdywgqgttvtvss

SCOPe Domain Coordinates for d1qfwh_:

Click to download the PDB-style file with coordinates for d1qfwh_.
(The format of our PDB-style files is described here.)

Timeline for d1qfwh_: