SCOPe 2.07: Domain d2fy4a1: 2fy4 A:11-391

Lineage for d2fy4a1 (2fy4 A:11-391)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.43: CoA-dependent acyltransferases [52776] (1 superfamily)
   core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest

4. Superfamily c.43.1: CoA-dependent acyltransferases [52777] (5 families)

5. Family c.43.1.3: Choline/Carnitine O-acyltransferase [82424] (3 proteins)
   Pfam PF00755; monomeric enzyme containing tandem repeat of two CAT subunit-like domains

6. Protein Choline O-acetyltransferase [110591] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [225187] (4 PDB entries)

8. Domain d2fy4a1: 2fy4 A:11-391 [204277]
   automated match to d1q6xa1
   complexed with coa

Details for d2fy4a1

PDB Entry: 2fy4, 2.3 Å

PDB Description: structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis

PDB Compounds: (A:) choline O-acetyltransferase

SCOPe Domain Sequences for d2fy4a1:

Sequence, based on SEQRES records:

>d2fy4a1 c.43.1.3 (A:11-391) Choline O-acetyltransferase {Human (Homo sapiens) [TaxId: 9606]}
sglpklpvpplqqtlatylqcmrhlvseeqfrksqaivqqfgapgglgetlqqkllerqe
ktanwvseywlndmylnnrlalpvnsspavifarqhfpgtddqlrfaaslisgvlsykal
ldshsiptdcakgqlsgqplcmkqyyglfssyrlpghtqdtlvaqnssimpepehvivac
cnqffvldvvinfrrlsegdlftqlrkivkmasnaaarlppiglltsdgrsewaeartvl
vkdstnrdsldmierciclvcldapggvelsdthralqllhgggysknganrwydkslqf
vvgrdgtcgvvcehspfdgivlvqctehllkhmtqpelvrspmvplpaprrlrwkcspei
qghlassaeklqrivknl

Sequence, based on observed residues (ATOM records):

>d2fy4a1 c.43.1.3 (A:11-391) Choline O-acetyltransferase {Human (Homo sapiens) [TaxId: 9606]}
sglpklpvpplqqtlatylqcmrhlvseeqfrksqaivqqfgapgglgetlqqkllerqe
ktanwvseywlndmylnnrlalpvnsspavifarqhfpgtddqlrfaaslisgvlsykal
ldshsiptdcakgqlsgqplcmkqyyglfssyrlpghtqdtlvaqmpepehvivaccnqf
fvldvvinfrrlsegdlftqlrkivkmasnaaarlppiglltsdgrsewaeartvlvkds
tnrdsldmierciclvcldapggvelsdthralqllhgggysknganrwydkslqfvvgr
dgtcgvvcehspfdgivlvqctehllkhmtqpelvrspmvplpaprrlrwkcspeiqghl
assaeklqrivknl

Timeline for d2fy4a1:

• d2fy4a1 first appeared in SCOPe 2.03
  
• d2fy4a1 appears in SCOPe 2.06
  
• d2fy4a1 appears in the current release, SCOPe 2.08