SCOPe 2.06: Domain d2fmnc_: 2fmn C:

Lineage for d2fmnc_ (2fmn C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

8. Domain d2fmnc_: 2fmn C: [204231]
   automated match to d1b5tb_
   complexed with 4hf, fad; mutant

Details for d2fmnc_

PDB Entry: 2fmn, 2.05 Å

PDB Description: ala177val mutant of e. coli methylenetetrahydrofolate reductase complex with ly309887

PDB Compounds: (C:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d2fmnc_:

Sequence, based on SEQRES records:

>d2fmnc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
gqinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdr
tgleaaphltcidatpdelrtiardywnngirhivalrgdlppgsgkpemyasdlvtllk
evadfdisvaaypevhpeaksaqadllnlkrkvdagvnraitqfffdvesylrfrdrcvs
agidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdm
vkilsregvkdfhfytlnraemsyaichtlgvrpgl

Sequence, based on observed residues (ATOM records):

>d2fmnc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
gqinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdr
tgleaaphltcidatpdelrtiardywnngirhivalrgdlppemyasdlvtllkevadf
disvaaypevhpeaksaqadllnlkrkvdagvnraitqfffdvesylrfrdrcvsagidv
eiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmvkils
regvkdfhfytlnraemsyaichtlgvrpgl

Timeline for d2fmnc_:

• d2fmnc_ first appeared in SCOPe 2.03
  
• d2fmnc_ appears in SCOPe 2.05
  
• d2fmnc_ appears in SCOPe 2.07
  
• d2fmnc_ appears in the current release, SCOPe 2.08