SCOPe 2.04: Domain d2cjza_: 2cjz A:

Lineage for d2cjza_ (2cjz A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (6 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (86 PDB entries)

8. Domain d2cjza_: 2cjz A: [203799]
   automated match to d2hvla_
   complexed with edo, ptr; mutant

Details for d2cjza_

PDB Entry: 2cjz, 1.7 Å

PDB Description: crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine

PDB Compounds: (A:) human protein tyrosine phosphatase ptpn5

SCOPe Domain Sequences for d2cjza_:

Sequence, based on SEQRES records:

>d2cjza_ c.45.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nlyfqsmsrvlqaeelhekaldpfllqaeffeipmnfvdpkeydipglvrknryktilpn
phsrvcltspdpddplssyinanyirgyggeekvyiatqgpivstvadfwrmvwqehtpi
ivmitnieemnekcteywpeeqvaydgveitvqkvihtedyrlrlislksgteerglkhy
wftswpdqktpdrappllhlvreveeaaqqegphcapiivhssagigrtgcfiatsiccq
qlrqegvvdilkttcqlrqdrggmiqtceqyqfvhhvmslyekqls

Sequence, based on observed residues (ATOM records):

>d2cjza_ c.45.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nlyfqsmsrvlqaeelhekaldpfllqaeffeipmnfvdpkeydipglvrknryktilpn
phsrvcltspdpddplssyinanyirgyggeekvyiatqgpivstvadfwrmvwqehtpi
ivmitteywpeeqvaydgveitvqkvihtedyrlrlislkseerglkhywftswpdqktp
drappllhlvreveeaaqqegphcapiivhssagigrtgcfiatsiccqqlrqegvvdil
kttcqlrqdrggmiqtceqyqfvhhvmslyekqls

Timeline for d2cjza_:

• d2cjza_ first appeared in SCOPe 2.03
  
• d2cjza_ appears in SCOPe 2.05
  
• d2cjza_ appears in the current release, SCOPe 2.08, called d2cjza1